Toxoplasma Serum Test Cassette

One-step TOXO IgM and TOXO IgG Test Devices

Toxoplasma (TOXO) screen tests can be divided into two types, according to the antibody type to be tested, namely TOXO IgM test and TOXO IgG test. The two TOXO rapid tests are based on the principle of Gold Immuno-chromatography Assay (GICA), using the antibody-antigen reaction to detect IgM and IgG antibodies in human serum or plasma specimen respectively.

With an TOXO IgM assay, when the serum sample added contains TOXO-IgM, the antibody will react with anti-human IgM monoclonal antibody in the membrane strip. These complexes move along the membrane strip chromatographically to the test region (T), where these complexes will be captured by the pre-coated recombinant TOXO antigen. Then a red or pink line will appear, indicating a positive result. The unbounded complex moves on to the control region (C), where they are captured by the anti-mouse antibody, and a red line will appear, indicating the assay is a valid one. In this way, the control line provides an inner quality control mechanism for this TOXO serum test. For a TOXO IgG assay, the principle is the same.

TOXO Fetus Health tests and Toxoplasmosis

Toxoplasmosis (TOXO) is a systemic disease, caused by the protozoa Toxoplasma gondii. Infection in Immuno-compromised patients and in the developing fetus can lead to serious consequences. Opportunistic toxoplasmosis infection or reactivation of a subclinical infection in Immuno-compromised patients may cause encephalitis, pneumonitis and myocarditis. In the congenitally infected fetus the infection may spread to the central nervous system. Abortion and stillbirth may occur when infection takes place during the first trimester of pregnancy, and irreversible neurological damages in case of infection during the second or third trimester. By detecting the Toxoplasma specific antibodies in serum samples, and by differentiating the IgM and IgG antibodies, these two TOXO antibody tests can help to determine the immune status and the infection status of the patient, thus help administration properly.