CMV IgM & CMV IgG Rapid Test

One-step Cytomegalovirus (CMV) Screening Test Devices

Cytomegalovirus (CMV) screen tests can be divided into two types, according to the antibody type to be tested, CMV IgM test and CMV IgG test. The two CMV rapid tests are based on the principle of Gold Immuno-chromatography Assay (GICA), using the antibody-antigen reaction to detect CMV IgM and IgG antibodies in human serum or plasma specimen respectively.

These Cytomegalovirus tests are IVD CMV test, and the assay principle are simple. With an CMV IgM assay, when the serum sample added contains CMV-IgM, the antibody will react with anti-human IgM monoclonal antibody in the membrane strip. These complexes move along the membrane strip chromatographically to the test region (T), where these complexes will be captured by the pre-coated recombinant CMV antigen. Then a red or pink line will appear, indicating a positive result. The unbounded complex moves on to the control region (C), where they are captured by the anti-mouse antibody, and a red line will appear, indicating the assay is a valid one. In this way, the control line provides an inner quality control mechanism for this CMV serum test. For a CMV IgG assay, the story is the same.

The detecting of CMV IgM antibody enables effective diagnosis of acute or recent CMV infection. The test is particularly useful for the follow-up of pregnant women, who were not previously exposed to CMV and consequently are not protected against the virus. In addition, determination of specific IgM antibody in the newborn is useful for the diagnosis of congenital CMV infection. Screening for IgG antibodies to CMV is useful to detect previous exposure to CMV. By detecting the Cytomegalovirus specific antibodies in serum samples, and by differentiating the IgM and IgG antibodies, these two CMV antibody tests can help to determine the immune status and the infection status of the patient, thus Cytomegalovirus tests help disease administration properly.